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Observe Carefully (one)pentobarbital will minimize the extent or influence of glecaprevir/pibrentasvir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the extent or influence of alprazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.If phenobarbital and doxycycline are administe